FPUS42 KMLB 172010 City Forecast for Sanford, FL Issued Tuesday afternoon - Dec 17, 2013 .Tuesday night... Low 46, 0% chance of precipitation. .Wednesday... Sunny, high 69, 0% chance of precipitation. .Wednesday night... Low 48, 0% chance of precipitation. .Thursday... Sunny, high 76. .Thursday night... Low 58.